Natural Remedies: A Potential Cancer Treatment
Oncology-Natural Remedies
Keywords:
Anticarcinogenic, Metastasis, Natural Remedies for Cancer, Cancer Therapies, ApoptosisAbstract
The discovery and development of multiple medications for the medical management of multiple kinds of cancer depend heavily on organic components. By modifying multiple pathways, including cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis, these phytochemicals have shown anticarcinogenic capabilities by preventing cancer onset, expansion, and spread. Treating complex disorders like cancer using drugs focusing on one aspect may have minimal efficacy and frequently result in poor results. Many epidemiological investigations have demonstrated a strong correlation between a regular intake of fruits and vegetables and a lower risk of cancer. Plants, herbs, and other natural items have been employed as therapeutic agents since ages ago. Similarly, most of the components used in medicines nowadays originate from natural sources. Despite successes, creating bioactive substances and pharmaceuticals using organic substances continue to be difficult, largely due to the issue of large-scale sequestration and mechanistic understanding. Researchers are possibly reaching a turning point when they should reassess strategies to discover promising natural products and explore their effectiveness as therapies due to substantial advancements in cancer therapy and the increased usage of modern technology. With an emphasis on solid cancer's root causes and molecular pathways, we review current natural product-based oncology research advancements, what they do, and how to generate innovative systemic therapies.
References
Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites. 2012 Apr 16;2(2):303-36. doi: 10.3390/metabo2020303, PMID 24957513, PMCID PMC3901206.
Loh CY, Chai JY, Tang TF, Wong WF, Sethi G, Shanmugam MK et al. The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges. Cells. 2019 Sep 20;8(10):1118. doi: 10.3390/cells8101118, PMID 31547193, PMCID PMC6830116.
Mendes AF, Caramona MM, Carvalho AP, Lopes MC. Role of mitogen-activated protein and tyrosine kinases on IL-1-induced NF-κB activation and iNOS expression in bovine articular chondrocytes. Nitric Oxide. 2002 Feb 1;6(1):35-44. doi 10.1006/nix.2001.0378, PMID 11829533.
Wei D, Xin Y, Rong Y, Hao Y. Correlation between the expression of VEGF and Ki67 and lymph node metastasis in non-small-cell lung cancer: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2022 Jun 28;2022:9693746. doi: 10.1155/2022/9693746, PMID 35800006.
Zhao Y, Yao J, Wu XP, Zhao L, Zhou YX, Zhang Y et al. Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in the inflammatory microenvironment by modulating the IL‐6/STAT3 signaling pathway. Mol Carcinog. 2015 Jul;54;Suppl 1:E81-93. doi 10.1002/mc.22182, PMID 24976450.
Karahan N, Baspinar S, Yariktas M, Kapucuoglu N. Matrix metalloproteinases (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) expressions in vocal fold polyps. J Voice. 2009 Jan 1;23(1):29-33. doi: 10.1016/j.jvoice.2007.05.005, PMID 17624726.
Huang Z, Yu P, Tang J. Characterization of triple-negative breast cancer MDA-MB-231 cell spheroid model. Onco Targets Ther. 2020;13:5395-405. doi: 10.2147/OTT.S249756, PMID 32606757.
Deng H, Liu J, Deng Y, Han G, Shellman YG, Robinson SE et al. CtBP1 is expressed in melanoma and represses the transcription of p16INK4a and BRCA1. J Invest Dermatol. 2013 May 1;133(5):1294-301. doi: 10.1038/did.2012.487, PMID 23303449.
Pratheeshkumar P, Sheeja K, Kuttan G. Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression. Immunopharmacol Immunotoxicol. 2012 Feb 1;34(1):143-51. doi: 10.3109/08923973.2011.588233, PMID 21682651.
Hafiz FB, Towfique NM, Sen MK, Sima SN, Azhar BS, Rahman MM. A comprehensive ethnopharmacological and phytochemical update review on the medicinal plant of Terminalia Arjuna Roxb of Bangladesh. Sch Acad. J Pharmacol. 2014;3:19-25.
Paśko P, Galanty A, Zagrodzki P, Żmudzki P, Bieniek U, Prochownik E et al. Varied effect of fortification of kale sprouts with novel organic selenium compounds on the synthesis of sulfur and phenolic compounds concerning cytotoxic, antioxidant, and anti-inflammatory activity. Microchem J. 2022 Aug 1;179:107509. doi: 10.1016/j.microc.2022.107509.
Adwas AA, Elkhoely AA, Kabel AM, Abdel-Rahman MN, Eissa AA. Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice. J Infect Chemother. 2016 Jan 1;22(1):36-43. doi 10.1016/j.jiac.2015.10.001, PMID 26603425.
Perrone D, Fuggetta MP, Ardito F, Cottarelli A, De Filippis A, Ravagnan G et al. Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases. Exp Ther Med. 2017 Jul 1;14(1):3-9. doi 10.3892/item.2017.4472, PMID 28672886.
Jantan I, Haque MA, Arshad L, Harikrishnan H, Septama AW, Mohamed-Hussein ZA. Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. J Nutr Biochem. 2021 Jul 1;93:108634. doi: 10.1016/j.jnutbio.2021.108634, PMID 33794330.
Chen G, Yi Z, Chen X, Ma X, Su W, Li X. Polyphenol nanoparticles from commonly consumed tea for scavenging free radicals, stabilizing Pickering emulsions, and inhibiting cancer cells. ACS Appl Nano Mater. 2021;4(1):652-65. doi: 10.1021/acsanm.0c02950.
La Marca M, Beffy P, Della Croce C, Gervasi PG, Iori R, Puccinelli E et al. Structural influence of isothiocyanates on the expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes. Food Chem Toxicol. 2012 Aug 1;50(8):2822-30. doi 10.1016/j.fct.2012.05.044, PMID 22664424.
Souza JA, Rossa CR, Garlet GP, Nogueira AV, Cirelli JA. Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease. J Appl Oral Sci. 2012;20(2):128-38. doi: 10.1590/s1678-77572012000200002, PMID 22666826.
Raad Z, Kamel YM, Waheed HJ. Effect of melatonin on superoxide dismutase (SOD) and kidney injury Molecule 1 (KIM-1) in the nephrotoxic male rat. HIV Nurs. 2022 Oct 17;22(2):1566-71.
Bonadio A, Oguche S, Lavy T, Kleifeld O, Shifman JM. Computational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to auto-cleavage. bioRxiv. 2023:2023-04.
Suryono S, Rohman MS, Widjajanto E, Prayitnaningsih S, Wihastuti TA. Colchicine as potential inhibitor targeting MMP-9, NOX2 and TGF-β1 in myocardial infarction: a combination of docking and molecular dynamic simulation study. J Biomol Struct Dyn. 2023 Jan 7:1-. doi 10.1080/07391102.2023.2166590.
GÖKÇE G, Karavana SY, BAĞRIYANIK HA, Pekçetİn Ç, YAPAR EA, TURAL GA et al. Design and in vitro, in vivo evaluation of antioxidant bioadhesive gels for burn treatment. Turk J Biol. 2022;46(3):251-62. doi: 10.55730/1300-0152.2613.
Fan J, Lan B, Yu J, Wang J, Ning K, Wang F et al. Determination of taurine in quadriceps femoris by high-performance liquid chromatography with precolumn derivatization. BIO Web Conf. 2022;55. doi: 10.1051/bioconf/20225501027.
Agrawal S, Karcher D, Ruf S, Erban A, Hertle AP, Kopka J et al. Riboswitch-mediated inducible expression of an astaxanthin biosynthetic operon in plastids. Plant Physiol. 2022 Jan;188(1):637-52. doi: 10.1093/plphys/kiab428, PMID 34623449.
Hughes SA, Lin M, Weir A, Huang B, Xiong L, Chua NK, et al. Caspase-8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency. EMBO J. 2023 Mar 1;42(5):e110468. doi 10.15252/bj.2021110468, PMID 36647737.
De Silva E, Devine DV, Jan E, Roskelley CD, Kim H. Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner. Biochem J. 2022 Nov 23;479(22):2351-64. doi: 10.1042/BCJ20220177, PMID 36239738.
Sharma A, Verma C, Mukhopadhyay S, Gupta A, Gupta B. Development of sodium alginate/glycerol/tannic acid coated cotton as an antimicrobial system. Int J Biol Macromol. 2022 Sep 1;216:303-11. doi: 10.1016/j.ijbiomac.2022.06.168, PMID 35777513.
Onwuha‐Ekpete L, Fields GB. Application of a triple-helical peptide inhibitor of MMP -2/ MMP -9 to examine T-cell activation in experimental autoimmune encephalomyelitis. Pept Sci. 2022 Sep;114(5):e24262. doi 10.1002/pep2.24262.
Tiwari R, Ghildiyal S, Gaur P, Fatima T, Upadhyay S, Srivastava JK et al. The relationship between MMP-2 rs243865, MMP-9 rs398242, and CXCL-12 rs1801157 gene polymorphisms with Japanese encephalitis disease and disease outcome in the north Indian population. J Vector Borne Dis. 2023 Jan 1;60(1):65-73. doi: 10.4103/0972-9062.361176, PMID 37026221.
Lorenzini E, Torricelli F, Zamponi R, Donati B, Manicardi V, Sauta E et al. KAP1 is a new non-genetic vulnerability of malignant pleural mesothelioma (MPM). NAR Cancer. 2022 Sep;4(3):zcac024. doi: 10.1093/narcan/zcac024, PMID 35910692.
Green DR. The mitochondrial pathway of apoptosis Part II: The BCL-2 protein family. Cold Spring Harb Perspect Biol. 2022 Jun 1;14(6):a041046. doi 10.1101/cshperspect.a041046, PMID 35701220.
Pizano-Andrade JC, Vargas-Guerrero B, Gurrola-Díaz CM, Vargas-Radillo JJ, Ruiz-López MA. Natural products and their mechanisms in potential photoprotection of the skin. J Biosci. 2022 Dec 13;47(4):77. doi 10.1007/s12038-022-00314-2.
Antonopoulou I, Sapountzaki E, Rova U, Christakopoulos P. Ferulic Acid From Plant Biomass: a Phytochemical With Promising Antiviral Properties. Front Nutr. 2021;8:777576. doi: 10.3389/fnut.2021.777576. PMID 35198583.
Monroy-Mora A, de Lourdes Mora-García M, Alheli Monroy Mora KA, Hernández-Montes J, García-Rocha R, Don-López CA et al. Inhibition of adenosine deaminase activity reverses resistance to the cytotoxic effect of high adenosine levels in cervical cancer cells. Cytokine. 2022 Oct 1;158:155977. doi 10.1016/j.cyto.2022.155977, PMID 35933851.
Chahardoli A, Hosseinzadeh L, Shokoohinia Y, Fattahi A. Production of rutile titanium dioxide nanoparticles by trans-ferulic acid and their biomedical applications. Mater Today Commun. 2022 Dec 1;33:104305. doi: 10.1016/j.mtcomm.2022.104305.
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