A Systematic Review of Medicinal Plants Used in The Treatment of Various Types of Cancer

Oncology-Medicinal Plants

Authors

  • Nithya. M Assistant Professor, Department of Pharmacology, Excel College of Pharmacy, Komarapalayam, Namakkal -637303, Tamilnadu, India.
  • Revathi. M Associate Professor, Department of Pharmacology, JKK Munirajah Institute of Health Sciences College of Pharmacy, T.N. Palayam, Erode - 638506, Tamilnadu, India.
  • Dhivya. M Assistant Professor, Department of Biomedical Engineering, Erode Sengunthar Engineering College, Thuduppathi, Perundurai, Erode – 638057, Tamilnadu, India.

Keywords:

Cancer, Symptoms, Diseases, Traditional medicines, and Drug discovery.

Abstract

Cancer is a category of diseases characterized by abnormal cell proliferation. Possible symptoms and signs include a lump, unusual bleeding, a persistent cough, unexplained weight loss, and a change in bowel habits. These signs could be cancerrelated but could also be due to other conditions. People are choosing to use natural plant items for cancer treatment more frequently in recent years due to concerns about side effects. Due to their effectiveness and lower toxicity compared to contemporary drugs, traditional medicines are supported by the World Health Organisation (WHO). The main goal of this review is to draw attention to the potential of recently discovered anticancer chemicals from traditional medicinal plants to be exploited as leads for the development of anticancer drugs. The current paper is an in-depth analysis of numerous literature sources. For researchers and scientists worldwide, this review is useful to investigate the medicinal value of herbal plants against cancer and develop new drugs from them. 

 

Author Biographies

Nithya. M, Assistant Professor, Department of Pharmacology, Excel College of Pharmacy, Komarapalayam, Namakkal -637303, Tamilnadu, India.

 

 

Revathi. M, Associate Professor, Department of Pharmacology, JKK Munirajah Institute of Health Sciences College of Pharmacy, T.N. Palayam, Erode - 638506, Tamilnadu, India.

 

 

Dhivya. M, Assistant Professor, Department of Biomedical Engineering, Erode Sengunthar Engineering College, Thuduppathi, Perundurai, Erode – 638057, Tamilnadu, India.

 

 

References

Dar RA, Shahnawaz M, Qazi PH. Natural product medicines: A literature update. Journal of Phytopharmacology. 2017;6(6):349-351.

Sandberg F, Corrigan D. Natural Remedies. Their Origins and Uses. Abingdon: Taylor and Francis; 2001.

Ramawat, K., Dass, S., Mathur, M. (2009). The Chemical Diversity of Bioactive Molecules and Therapeutic Potential of Medicinal Plants. In: Ramawat, K. Herbal Drugs: Ethnomedicine to Modern Medicine. Springer, Berlin, Heidelberg.

OchwangI, D.O., Kimwele, C.N., Oduma, J.A., Gathumbi, P.K., Mbaria, J.M. and Kiama, S.G. (2014) Medicinal plants used in treatment and management of cancer in Kakamega County Kenya, Journal of Ethnopharmacology, 151, pp. 1040-1055.

Cancer Research UK (2014) What is cancer? Available at: http://www.cancerresearchuk.org/about-cancer/what-iscancer (Accessed 23 January 2015).

Ochwang IDO, Kimwele CN, Oduma JA, Gathumbi PK, Mbaria JM, et al. (2014) Medicinal plants used in treating and managing cancer in Kakamega County Kenya. Journal of Ethnopharmacology.151 (3): 1040-1055.

(2010) Cancer Facts and Figures. Atlanta: American Cancer Society, USA.

(2006) Biotechnology Company dedicated to cancer treatment. American Cancer Society.

Boivin JF (1990) Second Cancers and other late side effects of Cancer Treatments. Cancer 65(S3): 770-775.

Yates JS, Mustian KM, Morrow GR, Gillies LJ, Padmanaban D, et al. (2005) Prevalence of complementary and alternative medicine use in cancer patients during treatment. Support Care Cancer 13(10): 806 - 811.

Wiman KG, Zhivotovsky B. Understanding cell cycle and cell death regulation provide novel weapons against human diseases.Journal of internal medicine.2017; 281:483–95.

Matsuoka T, Yashiro M. Biomarkers of gastric cancer. Current topics and future perspective.World Journal of Gastroenterology. 2018;24:2818–32.

Imran A, Qamar HY, Ali Q, Naeem H, Riaz M, Amin S, Kanwal N, Ali F, Sabar MF, Nasir IA. Role of Molecular Biology in Cancer Treatment: A Review Article. Iran J Public Health. 2017; 46:1475–85.

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A., 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. A cancer journal for clinicians.68, 394–424.

Jain, S.K. Dictionary of Indian Folk Medicine and Ethnobotany; Deep Publications: New Delhi, India, 1991.

Kumar, S.; Singh, R.; Dutta, D.; Chandel, S.; Bhattacharya, A.; Ravichandran, V.; Sukla, S. In Vitro Anticancer Activity of Methanolic Extract of Justiciaadhatodaleaves with Special Emphasis on Human Breast Cancer Cell Line. Molecules 2022, 27, 8222.

P.J. Houghton, D.N. Akunyili, Meroterpenoids and naphthaquinones from Kigeliapinnatabark, Phytochemistry 32 (1993) 1015–1018.

Sarah NaulikhaKituyiet al.,In vitro anti-cancer efficacy and Phyto-chemical screening of solvent extracts of Kigeliaafricana (Lam.) Benth,Heliyon 6 (2020) e04481.

Jeline Rani,In Vitro Anticancer Activity of Methanolic Leaf Extract of Vanda Spathulata (L.) Spreng - A Medicinally Important Orchid, Jundishapur Journal of Microbiology.2022; 15(1):1638-1645.

KanyanattKanokwiroonet al., Anti‐breast cancer potential of frullanolide from Grangeamaderaspatana plant by inducing apoptosis, Oncology Letters 17: 5283-5291, 2019.

Sharon Prince et al., Galeniaafricana plant extract exhibits cytotoxicity in breast cancer cells by inducing multiple programmed cell death pathways Saudi Pharmaceutical Journal 28 (2020) 1155–1165.

Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Przegla̜dGastroenterologiczny. 2019; 14(2):89-103.

Roshni K, Younis M, Ilakkiyapavai D, Basavaraju P, Puthamohan VM (2018) Anticancer Activity of Biosynthesized Silver Nanoparticles using MurrayakoenigiiLeaf Extract against HT-29 Colon Cancer Cell Line. Journal of Cancer Science Therapeutics.10: 072-075.

Sumalatha D, Antioxidant and Antitumor activity of Phyllanthusemblica in colon cancer cell lines, International journal of current Microbiology and Applied Sciences 2013;2(5):189-195.

Tambe R, Patil A, Jain P, Sancheti J, Somani G, Sathaye S. Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy. Pharmaceutical Biology.2017; 55:264–268.

Nelson et al., In vitro anticancer activity of Eclipta alba whole plant extract on colon cancer cell HCT-116BMC Complementary Medicine and Therapies (2020) 20:355.

Winitchaikul T, Sawong S, Surangkul D, Srikummool M, Somran J, Pekthong D, et al.,(2021) Calotropisgigantea stem bark extract induced apoptosis related to ROS and ATP production in colon cancer cells. PLoS ONE 16(8):e0254392. https://doi.org/10.1371/journal.Pone.0254392.

Awati, et al., Antioxidant and Cytotoxicity Study of Asparagus aethiopicus. Indian Journal of Pharmaceutical Education and Research. 2020;54(3)

Nugraha AS, Hadi NS, Siwi SU. Efekhepatoprotektifekstrakbuahmerah (Pandanus conoideusLam.) padahatimencitjantangalurswissinduksidengan CCL4. Journal NaturIndonesia. 2008; 11(1): 24-30.

Mishra J, Dromund J, Quazi SH, Karanki SS, Shaw JJ, Chen B, Kumar N. Prospective of Colon Cancer. Treatments and Scope for Combinatorial Approach to Enhanced Cancer Cell Apoptosis Critical reviews in oncology/hematology. 2013; 86(3): 232-250.

Azar Hosseini, Ahmad Ghorbani. Cancer therapy withphytochemicals: evidence from clinical studies. Avicenna journal of phytomedicine.2015;5(2): 84-97.

Padmalochana K Anticancer (liver cancer cell lines) and antioxidant activity of Cassia auriculata flower extract from acetone and methanol solvents. Journal of Drug Delivery and Therapeutics. 2018: 8(6); 274-278.

ShanthiNal., In Vitro Anticancer Activity of Methanol Extracts of Avicennia Marina (Forssk) Virehagainst Hepg2 Liver Hepatocellular Carcinoma Cancer Cell Line: 2018; 9(10):pp.29122-29126.

Sawong S, Pekthong D, Suknoppakit P, Winitchaikul T, Kaewkong W, Somran J, Intapa C, Parhira S, Srisawang P. Calotropisgigantea stem bark extracts inhibit liver cancer induced by diethyl nitrosamine. Science Report. 2022; 12(1):12151.

Win Darmanto, Anticancer Activity of Methanol Extract of Ficuscarica Leaves and Fruits against Proliferation, Apoptosis and Necrosis in Huh7it Cells. Cancer Informatics 2019; 18: 1–7.

Prabhakaranet al., Anticancer Activity of Hibiscus sabdariffaL(Flowers) against Human Liver Cancer (Hepg2) Cell Line International Journal of ChemTech Research, 2017, 10(12): 351-356.

S. McGuire, World Cancer Report 2014, World Health Organization, International Agency for Research on Cancer, WHO Press, Geneva, Switzerland, 2015.

R.S. Herbst, J.V. Heymach, S.M. Lippman, Lung cancer, N.The New England journal of medicine.359 (2008) 1367–1380.

M. Sajidet al. Potent anti-cancer activity of Alnusnitida against lung cancer cells; in vitro and in vivo studies Biomedicine & Pharmacotherapy 2019: 110 254–264.

Barung EN, Kalonio DE, Banne Y, Kambuno NT. Anticancer Activities of Sesewanua Leaf Extracts (Clerodendrumfragrans (Vent.) Wild) Against A549 Lung Cancer Cell. Open Access Macedonian Journal of Medical Sciences. 2021 Dec 15; 9(A):1226-1230.

HaritaRavikumar,et al., In-vitro Anticancer Activity of CardiospermumHalicacabum against Human A549 Lung Cancer Cell, Journal of Research in Medical and Dental Science 2022, 10 (1):335-338.

Cielo Mae D Marquez et al., AlangiumlongiflorumMerr. Leaf Extract Induces Apoptosis in A549 Lung Cancer Cells with Minimal NFκB Transcriptional Activation, Asian Pacific Journal of Cancer Prevention, 2020:21 (8); 2453-2461.

Imran aliet al., Anti-cancer and Anti-oxidant Potencies of CuscutareflexaRoxb. Plant Extracts,American Journal of Advanced Drug Delivery. 2020; 8(01): 01-11.

Ansari KN. The free radicals-the hidden culprits and update [J]. Indian journal of medical sciences.1997, 51(9): 319-336.

Beranek DT. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents [J]. Mutation research. 1990, 231(1): 11-30.

Javanmardi J, Stushnoff C, Locke E, et al. Antioxidant activity and total phenolic contant of Iranian Ocimum accessions [J]. Journal of Food Chemistry, 2003, 83(4): 547-550.

Mohammad Shoeb. Anticancer agents from medicinal plants [J]. Bangladesh Journal Pharmacology, 2006, 1: 35-41.

Isaac SilvèreGadeet al., Anticancer Activity of Combretumfragrans F. Hoffm on Glioblastoma and Prostate Cancer Cell Lines.2020:22 (4);1087-1093.

Gopalakrishnan VK et al.,Anticancer activity of the ethanolic extract of Cratevanurvala bark against testosterone and MNU-induced prostate cancer in rats, Chinese Journal of Natural Medicines 2012, 10(5): 0334−0338.

P N K, B R, Nair S S (December 16, 2022) Antiproliferative Action of Methanolic Petiole Extract of EichhorniaCrassipes on Human Prostate Adenocarcinoma Cell Line: An In Vitro Study. Cureus 14(12): e32616. DOI 10.7759/cureus.32616.

Murigendra B. Hiremath et al., In vitro antioxidant and anticancer activity of Leeaindica leaf extracts on human prostate cancer cell lines, Integrative Medicine Research, 2017, 79-87.

Youngmin Kang et al.,Root Extract of a MicropropagatedPrunusafricana Medicinal Plant Induced Apoptosis in Human Prostate Cancer Cells (PC-3) via Caspase-3 Activation Evidence-Based Complementary and Alternative Medicine.2022:1

Published

01-07-2023

How to Cite

M, N., R. M, and D. M. “A Systematic Review of Medicinal Plants Used in The Treatment of Various Types of Cancer: Oncology-Medicinal Plants”. International Journal of Trends in OncoScience, vol. 1, no. 3, July 2023, pp. 1-10, https://www.ijtos.com/index.php/journal/article/view/19.

Issue

Section

Review Articles